Activation of central trigeminovascular neurons by cortical spreading depression
نویسندگان
چکیده
منابع مشابه
Can cortical spreading depression activate central trigeminovascular neurons without peripheral input? Pitfalls of a new concept.
For the past 25 years, it has been hotly debated whether cortical spreading depression (CSD), the underlying mechanism of aura, can trigger migraine headache through activation of the trigeminovascular pain pathway. According to one school of thought, CSD leads to a cascade of molecular events (1) that activate pain fibers in meningeal areas overlying the affected cortices (2). According to ano...
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The effect of intra-carotid arterial infusions of glyceryl trinitrate (GTN), a substance known to precipitate headache, including migraine, upon the spontaneous activity of trigeminal neurons with craniovascular input was studied in cats. Second-order craniovascular neurons which received sensory input from the superior sagittal sinus were recorded in the trigeminal nucleus caudalis. Infusions ...
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Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods T...
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Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
متن کاملCannabinoid (CB1) receptor activation inhibits trigeminovascular neurons.
Migraine is a common and disabling neurological disorder that involves activation or the perception of activation of the trigeminovascular system. Cannabinoid (CB) receptors are present in brain and have been suggested to be antinociceptive. Here we determined the effect of cannabinoid receptor activation on neurons with trigeminovascular nociceptive input in the rat. Neurons in the trigeminoce...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 2011
ISSN: 0364-5134
DOI: 10.1002/ana.22329